Dynamic Penumbra Demonstrated by Sequential Multitracer PET after Middle Cerebral Artery Occlusion in Cats
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چکیده
منابع مشابه
Research Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
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A simple implantable device was applied to the left middle cerebral artery of adult cats. One week later the artery was occluded acutely while the animals were conscious. Forced circling and tonic deviation of the head and neck toward the left were noted within seconds of occlusion. A right hemiparesis developed one to two minutes later. Cerebral angiography confirmed the presence of the middle...
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Forty-four unanesthetized cats underwent temporary middle cerebral artery (MCA) occlusion with an implanted, externally controlled balloon cuff occluder. The occlusion was reversed to allow reperfusion of the MCA after 2 min to 24 hr of ischemia. Fourteen cats had temporary occlusions lasting 2 min to 3 hr; their neurological deficits improved or resolved after reperfusion, and brain sections s...
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We recorded regional cerebral blood flow, somatosensory evoked potentials, and auditory evoked potentials in the thalamic relay nuclei (ventral posterior lateral nucleus and medial geniculate body) and in the somatosensory and auditory cortices during and after 1 hour of transient left middle cerebral artery occlusion in nine cats. Regional cerebral blood flow was also measured in the thalamoco...
متن کاملHyperglycemia decreases acute neuronal ischemic changes after middle cerebral artery occlusion in cats.
Hyperglycemia has been reported to worsen the tolerance of the brain to ischemia, and it has therefore been recommended that patients undergoing neurosurgical procedures not receive glucose-containing solutions. However, whereas most animal studies have used global ischemia models, most neurosurgical procedures are associated with risks of focal rather than global ischemia. We therefore studied...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1994
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1994.120